Proven Technology

Graphic of a hand swirling 2oz of liquid in a glassGraphic of a hand swirling 2oz of liquid in a glass

Take a shot with more rapid absorption

CAMBIA is a diclofenac potassium formulation in 50-mg packets that was developed for acute treatment of migraine attacks with or without aura in adults.1

  • The potassium salt of diclofenac has a higher solubility in water than the sodium salt and is more rapidly absorbed2
  • Due to pH sensitivity, CAMBIA must be added to 1 to 2 ounces of only water for maximum absorption and effect2
  • When mixed with water, potassium bicarbonate helps to buffer the pH and increase the ionized form for more rapid absorption in the small intestine2


CAMBIA is designed to enhance the absorption of diclofenac:2

Graphic showing medication in waterGraphic showing medication in water


CAMBIA is designed to enhance the absorption of diclofenac:2

Combines diclofenac with a potassium bicarbonate buffer2

Graphic showing medication absorbing in stomachGraphic showing medication absorbing in stomach

Contains a buffer that allows diclofenac to remain in solution when CAMBIA enters the stomach, and may be responsible for an improved pharmacokinetic profile2*

  • Once mixed with water, the CAMBIA buffered preparation becomes more ionized2
  • In the acidic environment of the stomach, the ionized diclofenac is protonated and ready to be absorbed into the bloodstream2

*Interchangeability with other formulations of diclofenac

Different formulations of oral diclofenac are not bioequivalent even if the milligram strength is the same. Therefore, it is not possible to convert dosing from any other formulation of diclofenac to CAMBIA.1

Graphic showing medication entering brainGraphic showing medication entering brain

As a result, this formulation may lead to a shorter Tmax and a higher Cmax without an increase in overall systemic drug exposure [area under the curve (AUC)]3

Pharmacokinetic data do not predict clinical efficacy or safety.

See how patients can save with CAMBIASee how patients take CAMBIA
References: 1. CAMBIA [package insert]. Lake Forest, IL: Assertio Therapeutics, Inc.; 2017. 2. Chen C, Bujanover S, Kareht S, Rapoport AM. Differential pharmacokinetics of diclofenac potassium for oral solution vs immediate-release tablets from a randomized trial: effect of fed and fasting conditions. Headache. 2015;55(2):265-275. 3. Chuasuwan B, Binjesoh V, Polli JE, et al. Biowaiver monographs for immediate-release solid oral dosage forms: diclofenac sodium and diclofenac potassium. J Pharm Sci. 2009;98(4):1216-1219.