Single, 50-mg Dose Administration

Administer 1 packet (50 mg) of CAMBIA for the acute treatment of migraine attacks.1

  1. Empty the contents of 1 packet into a cup containing 1 to 2 ounces (30 to 60 mL) of water
  2. Mix well and drink immediately
  3. Do not use liquids other than water

Taking CAMBIA with food may cause a reduction in effectiveness compared to taking CAMBIA on an empty stomach. Please see DOSAGE AND ADMINISTRATION section of the full Prescribing Information for complete instructions on how to administer CAMBIA.


The most common adverse events (≥1% and greater than placebo) in clinical trials with CAMBIA were nausea and dizziness.

How to Prescribe

Prescribe the only single-agent NSAID for the acute treatment of migraine attacks.1

  1. Write a prescription for CAMBIA 50 mg, box of 9 packets
  2. Do not allow substitutions.
    According to approved FDA labeling, it is NOT possible to convert dosing from any other formulation of diclofenac to CAMBIA

Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals. The safety and effectiveness of a second dose have not been established.


Drugs That Interfere with Hemostasis (e.g. warfarin, aspirin, SSRIs/SNRIs):
Monitor patients for bleeding who are concomitantly taking CAMBIA with drugs that interfere with hemostasis. Concomitant use of CAMBIA and analgesic doses of aspirin is not generally recommended.

ACE Inhibitors and ARBs
Concomitant use with CAMBIA in elderly, volume depleted, or those with renal impairment may result in deterioration of renal function. In such high risk patients, monitor for signs of worsening renal function.

NSAIDs can reduce natriuretic effect of loop and thiazide diuretics. Monitor patients to assure diuretic efficacy including antihypertensive effects.

Concomitant use with CAMBIA can increase serum concentration and prolong half-life of digoxin. Monitor serum digoxin levels.

Please see full Prescribing Information for complete information about Drug Interactions.


1. CAMBIA [package insert]. Newark, CA: Depomed, Inc; 2016.